CRISPRi Paper out & 上原記念生命科学財団贈呈式・記念パーティー

March 11, 2016

 My colleague in the Conklin lab, Mo Mandegar, published his work on CRISPR interference (CRISPRi) in human iPS cells in Cell Stem Cell. The original CRISPR/Cas9 system recognizes and cuts specific sites in the genome, but the CRISPRi system utilizes catarytically-dead Cas9 fused to transcriptional repressor to inhibit gene expression. Mo has introduced CRISPRi into human iPS cells and demonstrated its power to study disease.

Mo and I started in the Conklin lab almost at the same time as postdocs. We were the first ones to use TALENs to edit the genome in the lab. It was still in the "pre-CRISPR era". Since then, I kind of stayed in the genome editing, and he shifted to the CRISPRi system.

Mo is a great scientist. He is also quite a character. We both like skiing and went up to the top of Big Sky, Montana together last year (picture). Scientifically and non-scientifically, I enjoy talking to him. I am so happy that his paper is finally out.



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