Genome Editing in Human iPS Cells to Study and Cure Disease

Human iPS (induced pluripotent stem) cells have the potential to allow us to study diseases in virtually any type of human cell, and develop cell transplantation-based therapies. Our team is developing and improving genome editing technology in iPS cells. We are developing novel isogenic iPS cell-based disease models, and correcting mutations in iPS cells from patients, a critical step in transplantation-based therapies. Our current focus is on diseases affecting cardiomyocytes and hepatocytes. →More


2021. 11. 25. Anri Saitoh wins the Ochanomizu University Outstanding Student Award in Biology.

2021. 11. 18. Kanata Imamura and Yuga Yasuda join the lab as interns.

2021. 11. 10. Miyaoka answers a question on liver regeneration in Kodomo no Kagaku (Kids' Science magazine).

2021. 11. 3. Genome edited iPS cell-based study on pathogenic mechanism of cardiomyopathy by RBM20 mutations is published in Nature Communications.

We revealed surprising smilarlities between cardiomyopathy and neurodgenerative diseases such as ALS (PDF).

Press relsease by Cincinnati Children's Hospital.

2021. 10. 5. A review on CRISPR-Cas9 by Nakajima and Miyaoka  is published in Clinical Immunology & Allergology (in Japanese)

2021. 9. 1. Miyaoka is now affiliated with Ochanomizu University as an associate professor

2021. 8. 10. Genome edited iPS cell-based study on pathogenic mechanism and therapeutic approaches of Wilson's disease is out at bioRxiv - Collaborative project with Dr. Yohei Hayashi at RIKEN BRC.

2021. 6. 28. We take lab photos.

2021. 6. 4. Genome edited iPS cell-based study on pathogenic mechanism of cardiomyopathy by RBM20 mutations is out at BioRxiv.

2021. 6. 3. Kayoko Shinozaki joins the lab as an intern.

2021. 5. 26. Comment on genome editing in Yomiuri Kids' Newspaper

2021. 4. 1. Anri Saitoh (officially) and Minato Maeda start their BS theses in the lab.

2021. 2. 27. Dr. Miyaoka together with Dr. Md. Shamsuzzoha Bayzid and Dr. Clara Li are awarded Interstellar Initiative (AMED, NYAS) Outstanding Presentation Award



2021. 12. 1-3. MBSJ2016 @ Pacifico Yokohama (Tomoko Kato and Daiki Kondo presenting)

2021. 12. 13. 4pm- Online Institutional Seminar by Dr. Keiichiro Ishiguro from Kumamoto University (Host).

2021. 12. 17. Seminar at Saitama Prefectural Kawagoe High School (Talk)

2022. 3. 17-19. The 21st Congress of the Japanese Society for Regenerative Medicine (Talk)