Paper on iPS Cell-Based Model of Wilson's Disease Published / ウィルソン病のiPS細胞モデルについての論文を発表
Our collaborative work with Dr. Yohei Hayashi's Lab at RIKEN BRC is out at Human Molecular Genetics. Wilson's disease is caused by mutations in ATP7B, which is a copper transporter. I started using an iPS cell line derived from a Wilson's disease patient harboring the homozygous ATP7B R778L mutation, when I was a postdoc in the US. Then, I initiated correction of the mutation and differentiation of the cells into hepatocytes after I came back to Japan. We realized that the R7
